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Frontiers | Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor | Immunolo

Carter PJ, Lazar GA. Next generation antibody drugs: pursuit of the 'high-hanging fruit'. Nat Rev Drug ... Kufer P, Lutterbuse R, Zettl F, Daniel PT, Schwenkenbecher JM, et al. A recombinant bispecific single-chain antibody, CD19 x CD3, induces rapid and high . ...

Delivery of Antibody Mimics into Mammalian Cells via Anthrax Toxin Protective Antigen - Liao - 2014 - ChemBioChem - Wiley Online Libra

Annual Review of Pharmacology and Toxicology, 57, 1, (39), (2017). Crossref N. Tsomaia , M. Ufret, A. Bhat and J. Nakhle, Future of Medicinal Chemistry: Next-Generation Therapeutics ...

Next generation antibody drugs: pursuit of the 'high-hanging fruit' | Thinkl

Also new online today: Next generation antibody drugs for the 'high-hanging fruit': difficult to hit, less well-understood or previously undruggable targets. go.nature.com/2ALJdeO pic.twitter.com/fWFTEezSsv 44 ...

Antibodies | Free Full-Text | Engaging with Raman Spectroscopy to Investigate Antibody Aggregation | HT

39]. Regardless of the Raman technique applied in the study of protein aggregates, ... P.J.; Lazar, G.A. Next generation antibody drugs: Pursuit of the ‘high-hanging fruit’. Nat. Rev. Drug Discov. 2018, 17, 197–223. [Google Scholar] [] [] Reichert, J.MMAbs ...

pH-dependent antigen-binding antibodies as a novel therapeutic modality. - Semantic Schol

A pH-dependent binding antibody against a soluble antigen can be further improved by Fc engineering to enhance the Fc receptor binding. Various approaches, including histidine-based engineering, direct cloning from immunized animals, and synthetic and have ...

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics - Bioconjugate Chemistry (ACS Publication

Next generation antibody drugs: pursuit of the 'high-hanging fruit' Paul J. Carter, Greg A. Lazar Nature Reviews Drug Discovery 2017 17 (3) ...

Next generation antibody drugs: Pursuit of the 'high-hanging fruit' | Paul J. Cart

Download Citation on ResearchGate | Next generation antibody drugs: Pursuit of the 'high-hanging fruit' | Antibodies are the most rapidly growing drug class and have a major impact on human health, particularly in oncology, autoimmunity and chronic inflammatory ...

Next generation antibody drugs: pursuit of the 'high-hanging fruit

Next generation antibody drugs: pursuit of the 'high-hanging fruit' Next generation antibody drugs: pursuit of the 'high-hanging fruit', Published online: 01 December 2017; doi:10.1038/nrd.2017.227 Antibody therapeutics are now established as a major drug class.

Next generation antibody drugs: pursuit of the .

antibody–drug conjugates, bispecific antibodies and antibody engineering to facilitate more effective delivery. These strategies could enable the pursuit of difficult to hit, less well-understood or previously undruggable targets — the 'high-hanging fruit ...

Application Note: Accelerating the Antibody Discovery Proce

antibody discovery workflow involves the fusion of murine B cells from immunized mice with a myeloma line for the generation of ... G. A. Next generation antibody drugs: Pursuit of the ‘high-hanging fruit’. Nat. Rev. Drug Discov. 17, 197–223 (2018). ...

Monoclonal antibody - Wikiped

Several monoclonal antibody technologies had been developed recently, such as phage display, ... and involved high throughput screening of antibody libraries against diseased and non-diseased tissue, whilst Proximol used a free radical enzymatic reaction to , ...

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics | Bioconjugate Chemist

Next generation antibody drugs: pursuit of the 'high-hanging fruit'. Nature Reviews Drug Discovery 2017, 17 (3) , 197-223. ... Pharmacokinetic and pharmacodynamic considerations for the next generation protein therapeutics. Journal of Pharmacokinetics and 2015

Monoclonal antibody - Wikiped

Several monoclonal antibody technologies had been developed recently, such as phage display, ... and involved high throughput screening of antibody libraries against diseased and non-diseased tissue, whilst Proximol used a free radical enzymatic reaction to , ...

Next generation antibody drugs: pursuit of the 'high-hanging fruit' | Nature Reviews Drug Discove

Next generation antibody drugs: pursuit of the 'high-hanging fruit' Paul J. Carter 1 Paul J. Carter is Senior Director of Antibody Engineering and a staff scientist at Genentech, South San Francisco, California, USA. His research interests focus on creating new ...

Development of an analytical method to assess the occupational health risk of therapeutic monoclonal antibodies using LC-HRMS | SpringerLi

Monoclonal antibody Occupational exposure Sensitising High-resolution mass spectrometry Airborne ... Carter PJ, Lazar GA. Next generation antibody drugs: pursuit of the high-hanging fruit. Nat Rev Drug Discov. 2017; ...

Monoclonal antibody biosimilars | Nature Reviews Drug Discove

Monoclonal antibody biosimilars Natasha Udpa 1 & Ryan P. Million 1 Nature Reviews Drug Discovery volume 15, pages 13 – 14 (2016 ... Next generation antibody drugs: pursuit of the 'high-hanging fruit' Paul J. Carter & Greg A. Lazar Host cell , ...

Orthogonal Cysteine Protection Enables Homogeneous Multi‐Drug Antibody–Drug Conjugates - Semantic Schol

A strategy for the preparation of homogeneous antibody-drug conjugates (ADCs) containing multiple payloads has been developed. ... it is widely applicable and enables high drug loading for improved ADC potency. To highlight the benefits of ADC dual drug this ...

The evolving landscape of ‘next-generation’ immune checkpoint inhibitors: A review - ScienceDire

Drugs targeting these pathways (‘next-generation’ immune modulators, NGIMs) constitute a major frontier in translational research and have generated unprecedented scientific and financial investment. Here, we systematically reviewed published literature ...

Pharmacokinetic and Immunological Considerations for Expanding the Therapeutic Window of Next-Generation Antibody–Drug Conjugates | SpringerLi

Carter PJ, Lazar GA. Next generation antibody drugs: pursuit of the “high-hanging fruit”. Nat Rev Drug Discov. 2018;17:197–223. CrossRef PubMed Google Scholar 4. ...

Next generation antibody drugs: pursuit of the 'high-hanging fruit' | Chemsrc ID:12895

Chemsrc article ID 1289567 's abstract:Next generation antibody drugs: pursuit of the 'high-hanging fruit' Next generation antibody drugs: pursuit of the 'high-hanging fruit', Published online: 01 December 2017; doi:10.1038/nrd.2017.227Antibody ...